Föredrag om sött blod i Helsingborg på onsdag

13 oktober, 2013

På onsdag blir det föredrag i Jacob Hansens hus i Helsingborg, 18.00-20.30. Det anordnas av Bröstcancerföreningen Pärlan och det är fritt inträde. Första timmen kommer handla om granskningen av våra kostråd, följt av cirka 40 minuter som handlar specifikt om cancer. Det är ingen föranmälan, utan först till kvarn gäller. Men jag tror att det kommer att finnas tillräckligt med platser åt alla. Den som vill kan köpa boken till specialpris: 160 kronor för en eller 300 kronor för två böcker. VÄLKOMNA!

Här är schemat för höstens kommande offentliga föredrag:

23 oktober 19.00-20.30, Womens Wellness, Uppsala

Läs och anmäl dig via denna länk: Womens Wellness Uppsala

6 november 18.00-20.00, CrossFit Holistic, Luleå

Läs och anmäl dig via denna länk: CrossFit Holistic Luleå

7 november 19.00-20.oo, lokalen Krokodil, Piteå

Piteå Nya FöreläsningsFörening anordnar detta föredrag. Mer info hittar du på: www.krokodil.nu

13 november 19.00, PriMaten Science Park, Uppsala

Återkommer med mer info här.

20 november 18.00-19.00, Folkuniversitetet Stockholm

Detta är ett samarbete med Forskning och framsteg. Föredraget är fullbokat.

27 november 14.00, Laholm

Föredraget anordnas av Laholms Socialförvaltning, preventionsavdelningen. Det är öppet för alla som är lediga. Återkommer med plats.

Till våren är det också föredrag inplanerade i Olofström, 23 januari, och 25 mars på biblioteket i Avesta. Det kommer att komma mer info om detta längre fram. Men bor du i krokarna, kan du boka dessa datum redan nu.



  • Richard Arppe

    Peter Libby från Harvard intervjuad (2013)
    http://www.practiceupdate.com/expertopinion/456

    ”Dr. Libby: LDL is a causal risk factor for atherosclerosis. We have genetic evidence. We have epidemiologic, observational, prospective observational data and trial data that really meet the modified Koch’s postulates to identify LDL as a causal risk factor.

    The statin class of drugs has really transformed cardiovascular medicine and, pretty consistently, is able to, not only achieve substantial reductions in LDL levels, but also a corresponding decrease in events in broad swaths of patients—not in all categories, but most of them. That’s why I think the pendulum has swung a little back toward LDL these days.

    All of the trials of aggressive LDL management vs less aggressive management have tended to show abenefit for the “even lower is better” hypothesis. Perhaps atherosclerosis would not be an epidemic if we walked around with LDL levels of 40 or 50 mg/dL”.

    Jag äter själv väldigt low-fat, high starch veganisk diet och min LDL är 1,8mmol/l (70mg/dl), som är ungefär den övre gränsen man träffar bland free-ranging mammalians. Kompis äter likadan kost och har sin LDL 1,3mmol/l (50mg/dl). Aporna i naturen har sin LDL 1-1,8mmol/l nivån.

    ”Several lines of evidence suggest that plasma levels of LDL-cholesterol in the range of 25-60 mg/dl (total plasma cholesterol of 110 to 150 mg/dl) might indeed be physiologic for human beings. First, in other mammalian species that do not develop atherosclerosis, the plasma LDL-cholesterol level is generally less than 80 mg/dl. In these animals the affinity of the LDL receptor for their own LDL is roughly the same as the affinity of the human LDL receptor for human LDL, implying that these species are designed by evolution to have similar plasma LDL levels. Second, the LDL level in newborn humans is approximately 30 mg/dl, well within the range that seems to be appropriate for receptor binding. Third, when humans are raised on a low fat diet, the plasma LDL-cholesterol tends to stay in the range of 50 to 80 mg/dl. It only reaches levels above 100 mg/dl in individuals who consume a diet rich in saturated animal fats and cholesterol that is customarily ingested in Western societies”

    –Brown & Goldstein 1985

    • Inger

      Tack för ett bra föredrag i Helsingborg! Även om man har läst boken var det härligt att höra dig live och du är en mycket bra föreläsare <3

  • Ullis

    Jag kommer till föredraget i Piteå. Ska bli väldigt intressant, trots att jag läst boken.

  • Richard Arppe

    John LaRosa, president of SUNY downstate medical center:

    More evidence for lowering LDL to below 70 (2011)

    ”LaRosa, who wrote an editorial [3] accompanying Lee’s study, expanded on his views to heartwire: ”I used to be skeptical about the idea of trying to achieve very low cholesterol levels, but now I am more accommodating. As cholesterol levels are coming down, we are seeing much lower rates of bypass surgery and elective angioplasty. I think elective angioplasty will eventually disappear altogether.”

    ”Chimpanzees eat very little fat. They have LDL levels in the range of 40 to 70, and they don’t get atherosclerosis. He noted that levels of LDL below 70 are on a par with those of nonhuman primates who don’t develop atherosclerosis, adding that, like these primates, humans were designed to be vegetarians. ”Our dental anatomy suggests that we are not meant to be meat eaters. Animals that eat meat have sharp tearing teeth, while we have flatter teeth more similar to vegetarian animals. I believe humans are not anatomically or metabolically designed to be meat eaters, and because we do consume animal fat that’s why we get atherosclerosis. Chimpanzees don’t eat meat; they eat very little fat. They have LDL levels in the range of 40 to 70, and they don’t get atherosclerosis. Maybe we wouldn’t get atherosclerosis either if we had levels this low”

    http://www.theheart.org/article/1290061.do

    Ann, viste du att traditionell kost i Okinawa innhehåller ungefär 6% av fett och 85% carbohydrat (table 1). 70% av kalorier kom från sötpotatis. Människor i Okinawa har ganska låg HDL-C kolesterol, men nästan ingen atherosclerosis. De har väl också låga LDLs.
    http://www.okicent.org/docs/anyas_cr_diet_2007_1114_434s.pdf

    • AnnFernholm

      Trevligt!

      • Richard Arppe

        The best kept secret of diet-heart denialists.

        Diet-heart: a problematic revisit (by Jeremiah Stamler)
        http://ajcn.nutrition.org/content/91/3/497.full

        Mättade fetter kopplad till 32% ökning av fatal hjärtkatastrof trotts regression dilution bias och trotts over-adjustments by serum lipids och trotts andra saker som högt sannolikt dilute the findings.

        ”To neglect this fact in a review about humans is to imply that the Darwinian foundation of biomedical research is invalid and/or that there is a body of substantial contrary evidence in humans. Neither is the case. Dietary cholesterol (as well as SFA) adversely influences human serum lipid concentrations, per cited equations. And several prospective epidemiologic studies found direct relations of dietary cholesterol to CHD independent of serum total cholesterol (6). The SFA-CHD relation can be soundly elucidated only with concurrent consideration of dietary cholesterol (as well as PUFA, carbohydrate, etc). The quality of the current 2 articles (1, 2) is impaired by inadequate attention to dietary cholesterol”.

        –Jeremiah Stamler (2011)

        • AnnFernholm

          Cochrane, som ett exempel, håller inte med dig.

          • Richard Arppe

            Tycker du att Cohrane är större än den 92-årig Jeremiah Stamler som är ju faktiskt Ancel Keys heir? Man kan ju säga att Cochrane håller inte alls med dig, trotts allt de är ju emot mättade fetter.
            http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD002137.pub3/abstract

            Anyways, The reduction in LDL and total cholesterol in these reduced fat randomized controlled trials included in the Cochrane meta-analysis was very minimal. As it has been demonstrated in dozens of rigorously controlled metabolic ward trials that replacing saturated fat with carbohydrates significantly lowers total and LDL cholesterol, the lack of decrease of LDL and total cholesterol likely reflects lack of appropriate dietary changes required to test the diet-heart hypothesis. The RR of 0.96 for cardiovascular mortality in the Cochrane meta-analysis is consistent with the expected results when considering the small decrease in LDL cholesterol.

            The Womens Health Initiative which was given the majority of the weight in the Cochrane meta-analysis was not even designed to lower LDL cholesterol, and as a result reductions in saturated fat intake and LDL cholesterol were fairly negligible. As the researchers of the WHI stated:

            “Because there are no apparent changes that would have mitigated a potentially favorable effect on CVD, the lack of an appreciable CVD effect maybe attributable to the limited decrease(only 2.7 mg/dL [0.07 mmol/L]) in LDL-C level, as well as the modest differences in other potentially favorable dietary components. Based on a large body of evidence from LDL-C–lowering trials, this magnitude of change in LDL-C level would be predicted to produce only a small (2%-4%) decrease in CVD risk, a value far below the power for detection in the current study. As delivered, the dietary intervention was not expected to have substantial effects on lipoprotein levels, but it is possible that a diet specifically lower in saturated and trans fat combined with increased intakes of vegetables ,fruits, and grains might have led to a decrease in CVD risk.”

            The researchers of the WHI also stated:

            “Compared with those in the entire comparison group, a trend was observed toward reduction of CHD risk among those in the intervention group who reached the lowest levels of saturated fat (HR, 0.81; 95% CI, 0.69-0.96 in the group that consumed <6.1% energy; P<.001 [adjusted HR, 0.82; 95%CI, 0.67-0.99; P=.05])… While these additional analyses are subject to residual confounding because of reporting bias or the lack of a comparable comparison group, some confidence in their validity is supported by parallel patterns of LDL-C reductions in participants stratified by changes in saturated fat at year 1 (−10.1; 95% CI, −13.5 to −6.6 mg/dL[0.26; 95% CI, −0.36 to −0.17 mmol/L]in the quartile with the greatest reduction;P=.005 for trend)”

            http://jama.jamanetwork.com/article.aspx?articleid=202339

  • Maria

    Tack för en superbra föreläsning i Helsingborg igår! Visserligen inga nyheter för mig men bra information som du lagt upp på ett bra sätt. Det hade varit roligt att i framtiden kunna gå på en liknande föreläsning med fokus på typ 1 diabetiker!!
    Men så länge, stort tack för ditt engagemang i dessa viktiga frågor!

  • AnnFernholm

    Tack! Ja, det där med typ 1 skulle behöva sig en genomgång…

  • AnnFernholm

    Tack så jättemycket!!!